Formulation and Development of SNEDDS for the Enhancement of Oral Bioavailability of Lipophilic Drugs

  • Meenakshi Chauhan, Kreetika, Dr. Anoop Kumar

Abstract

Pharmaceutical drugs which belong to BCS class II have poor oral bioavailability due to their limited aqueous solubilities. With the present investigations, it may be concluded that SNEDDS of a poorly soluble drug diclofenac sodium were successfully developed and optimized using the systematic approach of design of experiments (DoE).diclofenac sodium is an orally administered ACE inhibitor with poor solubility, stability and oral bioavailability. The objective of our investigation was to formulate self-nanoemulsifying drug delivery system (SNEDDS) of diclofenac sodium using oil, surfactant and co surfactant that could improve its solubility, stability and oral bioavailability.Optimized liquid SNEDDS formulation showed 96.19 % of drug diffusion with 50 nm droplet size, -23.2 mV Zeta potential and had infinite dilution capability.

Published
2022-03-18
How to Cite
Meenakshi Chauhan, Kreetika, Dr. Anoop Kumar. (2022). Formulation and Development of SNEDDS for the Enhancement of Oral Bioavailability of Lipophilic Drugs. Design Engineering, (1), 2586 - 2593. Retrieved from http://thedesignengineering.com/index.php/DE/article/view/9278
Section
Articles